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Cimetidine
In previous research studies, when cimetidine and sildenafil citrate were given at the same time, the levels of Viagra in the blood increased significantly. To avoid this possible sildenafil citrate drug interaction, it is recommended that you discuss alternatives with your healthcare provider prior to taking sildenafil citrate.
Ritonavir and Other Protease Inhibitors
Taking both sildenafil citrate and ritonavir (a protease inhibitor) together can significantly increase the levels of sildenafil citrate in the body. Sildenafil citrate should therefore be used with caution in people taking ritonavir. Sildenafil citrate has no effects on the levels of ritonavir in the body.
While sildenafil citrate has not been studied with other protease inhibitors, a similar reaction is expected.
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